{
  "schema_version": "1.0",
  "updated_at": "2026-10-23",
  "editorial_scope": "Evergreen explanatory topic page / evidence and linked news",
  "topic": "AI in Medicine",
  "canonical_url": "https://cortist.com/ai-in-medicine/",
  "source_list": [
    {
      "title": "Nature Reviews Drug Discovery: Where the field stands",
      "evidence_type": "Peer-reviewed / Aug 2026",
      "url": "https://www.nature.com/articles/s41573-026-01496-2"
    },
    {
      "title": "US FDA: Novel drug approvals",
      "evidence_type": "Official approval registry / 2026",
      "url": "https://www.fda.gov/drugs/novel-drug-approvals-fda/novel-drug-approvals-2026"
    },
    {
      "title": "US FDA: AI for drug development",
      "evidence_type": "Regulatory background",
      "url": "https://www.fda.gov/science-research/science-and-research-special-topics/artificial-intelligence-and-machine-learning-aiml-drug-development"
    },
    {
      "title": "Insilico Medicine: Phase III report",
      "evidence_type": "Company-reported trial milestone / Sep 2026",
      "url": "https://insilico.com/news/isn1009261-insilico-medicine-doses-first-patient-genesis-ipf-3"
    }
  ],
  "linked_cortist_news": [
    {
      "slug": "microsoft-mai-dxo-sequential-diagnosis-science-2026",
      "relationship": "RESEARCH / RETROSPECTIVE BENCHMARK",
      "warning": "Not a prospective clinical outcome or FDA drug approval."
    },
    {
      "slug": "huggingface-carbon-x-dna-model",
      "relationship": "RELATED RESEARCH",
      "warning": "Relevant biomedical AI research, but not evidence of clinical or FDA validation."
    }
  ],
  "primary_research_updates": [
    {
      "date": "September 10, 2026",
      "summary": "Insilico Medicine reported first dosing in a Phase III study of rentosertib. This is a company announcement and not an FDA approval or independent validation of de novo design.",
      "url": "https://insilico.com/news/isn1009261-insilico-medicine-doses-first-patient-genesis-ipf-3",
      "source_type": "Company trial update"
    },
    {
      "date": "August 7, 2026",
      "summary": "Nature Reviews Drug Discovery published a critical analysis of AI's practical contribution to drug discovery, emphasizing shortcomings in clinical translation and reliable attribution.",
      "url": "https://www.nature.com/articles/s41573-026-01496-2",
      "source_type": "Peer-reviewed perspective"
    }
  ],
  "forecast_candidate": "/forecast/ai-designed-drug-fda-approval-2032/",
  "working_probability_is_independently_approved": false,
  "news_update_policy": "Manual editorial curation on publication. Do not automatically claim topical news when only external research updates exist."
}